OESTROGEN DEPRIVATION INDUCES CHEMOKINE PRODUCTION AND IMMUNE CELL RECRUITMENT IN IN VITRO AND IN VIVO MODELS OF OESTROGEN RECEPTOR-POSITIVE BREAST CANCER

Abstract Background Oestrogen receptor-positive (ER+) breast cancer is commonly treated using endocrine therapies such as aromatase inhibitors which block synthesis of oestradiol, but the influence of this therapy on the immune composition of breast tumours has not been fully explored.Previous findings suggest that tumour infiltrating lymphocytes a

This writing aims to determine the application of the law against cyberbullying based on Article 27 of Law No.19 of 2016 concerning amendments to Law No.11 of 2008 on Electronic Information and Transactions.This research is able to provide a more comprehensive understanding, which focuses on the application of the principle of justice that will be

Traditionally in strength and conditioning environments, vibration has been transmitted using platforms, barbells, dumbbells, or cables but not suspension devices.This study aimed to examine the effects on the lower limb of applying superimposed vibration on a suspension device.Twenty-one physically active men and women performed supine bridge and

Germline CTLA-4 deficiency causes severe autoimmune diseases characterized by dysregulation of Foxp3+ Tregs, hyper-activation of effector memory T cells, and variable forms autoimmune cytopenia including gradual loss of B cells.Cancer patients with severe immune-related adverse events (irAE) after receiving anti-CTLA-4/PD-1 combination immunotherap